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NancyLebovitz comments on Open thread, Jan. 26 - Feb. 1, 2015 - Less Wrong Discussion

6 Post author: Gondolinian 26 January 2015 12:46AM

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Comment author: NancyLebovitz 27 January 2015 07:00:59PM 2 points [-]

Could someone get past the paywall for this?

It's a paper linking some commonly used prescription drugs to increased risk of dementia, and none of the popular press articles I've seen about it say how large the increased risk is.

Comment author: ike 28 January 2015 02:43:17AM 4 points [-]

http://www.nhs.uk/news/2015/01January/Pages/media-dementia-scare-about-common-drugs.aspx appears to have more info than the abstract.

Comment author: NancyLebovitz 28 January 2015 03:28:36AM 1 point [-]

Thank you. That was a lot easier to follow, and I might just make nhs.uk/news a habit.

Comment author: ike 28 January 2015 03:46:02AM 5 points [-]

What I usually do when articles are paywalled is do a search for the full title in quotes (i.e. https://www.google.com/search?q=%22Cumulative+Use+of+Strong+Anticholinergics+and+Incident+Dementia%22), which got me to https://dementianews.wordpress.com/, which linked to the nhs site. (https://dementianews.wordpress.com/2015/01/27/common-medicines-associated-with-dementia-risk-bbc-news-jama-internal-medicine/ for when it's no longer on the front page).

If the article is somewhere without a paywall, that will usually find it, and if not, I also check scholar and bing.

Comment author: Lumifer 27 January 2015 09:26:48PM *  1 point [-]

The basic results, including how large the risk increase is, are in the abstract at your link:

Results The most common anticholinergic classes used were tricyclic antidepressants, first-generation antihistamines, and bladder antimuscarinics. During a mean follow-up of 7.3 years, 797 participants (23.2%) developed dementia (637 of these [79.9%] developed Alzheimer disease). A 10-year cumulative dose-response relationship was observed for dementia and Alzheimer disease (test for trend, P < .001). For dementia, adjusted hazard ratios for cumulative anticholinergic use compared with nonuse were 0.92 (95% CI, 0.74-1.16) for TSDDs of 1 to 90; 1.19 (95% CI, 0.94-1.51) for TSDDs of 91 to 365; 1.23 (95% CI, 0.94-1.62) for TSDDs of 366 to 1095; and 1.54 (95% CI, 1.21-1.96) for TSDDs greater than 1095. A similar pattern of results was noted for Alzheimer disease. Results were robust in secondary, sensitivity, and post hoc analyses.

(TSDD is total standardized daily doses)

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