Jost comments on Harry Potter and the Methods of Rationality discussion thread, February 2015, chapter 113 - Less Wrong Discussion
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This would most likely require the Philosopher’s Stone to be in contact with the transfigured matter for several minutes (see chapter 111), which is impossible:
(chapter 15; emphasis mine)
The correct way to solve the problem is to apply another Transfiguration to turn the victim's body into its healthy form, then use the Philosopher's Stone to make the second Transfiguration permanent.
Is there a reason why this would not work?