If there are any significant brain changes, all the bets are off. The easiest brain change would be accepting psychedelics as part of religious practice. That wouldn't even take new technology.
However, it wouldn't surprise me if there's going to be intelligence increase technology and more sophisticated methods of emotional modification. I assume the desire for religion has something to do with brain chemistry/structure, and brain tech probably isn't going to be tested for how it affects religiosity.
Karen Armstrong has a theory that new religions arise (sometimes?) when a culture's methods of doing things are clearly not working. We could be heading into a period of institutional breakdown. If that leads to one or more major new religions, the details are assuredly not predictable.
I am reading Karen Armstrong's The Great Transformation: The Beginning of Our Religious Traditions now; it is really quite interesting. Armstrong is one of the best writers on religion that I have encountered.
This thread is for asking any questions that might seem obvious, tangential, silly or what-have-you. Don't be shy, everyone has holes in their knowledge, though the fewer and the smaller we can make them, the better.
Please be respectful of other people's admitting ignorance and don't mock them for it, as they're doing a noble thing.
To any future monthly posters of SQ threads, please remember to add the "stupid_questions" tag.