But when it comes to messy gene expression networks, we've already found the hidden beauty - the stable level of underlying physics. Because we've already found the master order, we can guess that we won't find any additional secret patterns that will make biology as easy as a sequence of cubes. Knowing the rules of the game, we know that the game is hard. We don't have enough computing power to do protein chemistry from physics (the second source of uncertainty) and evolutionary pathways may have gone different ways on different planets (the third source of uncertainty). New discoveries in basic physics won't help us here

Doesn't the third source of uncertainty violate Fermi Paradox and The Rare Earth hypothesis?