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Clarity comments on "Spiritual" techniques that actually work thread - Less Wrong Discussion
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Tried Ayahuasca. It works.
Hilarious ayahuasca tourism article on RationalWiki. Convinced me not to go do it, in tandum with warnings around DMT health and safety
If you are looking for an ayahuasca analogue that is easy to make yourself consider psilohuasca. Just don't do it alone if you have no experience and be careful with the dosage.
Yes there are dangers. Important to read up and have a safe setting. For me the biggest danger is fainting and hitting your head on the ground.