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MathiasZaman comments on Stupid Questions April 2015 - Less Wrong Discussion
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Knowing about the placebo effect doesn't stop the placebo effect from kicking in.
Anyway, I'd say that there are moments when comforting lies may be worth it, but I don't trust my ability to know when those moments are happening and it would raise my overall believability if I was found out.
Especially if you know that knowing about the placebo effect doesn't stop the placebo effect from kicking in.