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CellBioGuy comments on When does technological enhancement feel natural and acceptable? - Less Wrong Discussion
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Hmmm... we could define one.
We might need multiple axes though. One for thermodynamic implausiblity, one for dammit-thats-not-how-it-works-at-all / misapplication of programming concepts to chemistry, one for do-you-realize-how-complicated-what-you-just-suggested-is.