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Lumifer comments on A heuristic for predicting minor depression in others and myself, and related things - Less Wrong Discussion
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One strong confounder here is genes + culture.
To put it crudely, take an Italian to Finland and he'll diagnose 80% of Finns with depression. Take a Finn to Italy and he'll diagnose 80% of Italians with mania.
This is part of the reason I don't understand where the experts draw the line. You would think Canada and the UK are close enough culturally... I remember once a Canadian guy giving a sales demo to Brits and generally they they were annoyed how over-enthusiastic he was over it, and they considered it an American style getting imported into Canada... big full-toothed grins and all that. They were more or less thinking if you are happy about a product either you are stupid or think your audience is. Later on we discussed how best to sell things in the UK and an experienced entrepreneur told us smiles are okay but without showing teeth, as a 32-teeth grin would be too much enthusiasm.
There is no line, it's a continuous spectrum, and likely to be multidimensional, too :-/
tl;dr -- culture matters a lot.