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John_Maxwell_IV comments on LW should go into mainstream academia ? - Less Wrong Discussion
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Having a science replacement grow out of Givewell would be pretty interesting. I'll bet they'd do a better job of prioritizing research areas than government agencies like the National Science Foundation.
If you talk about "science replacement" you have to think about what science is. The German word for science is "Wissenschaft". The creation of knowledge. In particular the creation of reliable knowledge. GiveWell is engaged in that project.
According to Kuhn part of a scientific revolution is that the questions that get asked change.