This all hits the nail on the head I think. The marginal value of my PhD is, I'm convinced, at most zero, and perhaps negative, because it adds to the noise. The replicability of papers is significantly hindered by lack of automation, to my mind.

Also, saying that we don't know what 1/4 to 1/3 of human genes do is wildly optimistic. Better to say we have some idea what 2/3 of them do.