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Lumifer comments on Alien neuropunk slaver civilizations - Less Wrong Discussion
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I had in mind the ethical concerns of the OP. Economically, of course, wetware and silicon are rather different.
But you are correct to point out an issue relevant to the OP's question (can you make a superhuman AI out of biological brains) -- wetware scales rather poorly. At least the usual Earth's carbon-based wetware based mostly on chemistry in liquid and semi-liquid mediums.