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Unknowns comments on Two-boxing, smoking and chewing gum in Medical Newcomb problems - Less Wrong Discussion
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Even in the original Newcomb's problem there is presumably some causal pathway from your brain to your decision. Otherwise Omega wouldn't have a way to predict what you are going to do. And there is no difference here between "your brain" and the "gene" in the two versions.
In neither case does Omega cause your decision, your brain causes it in both cases.