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drethelin comments on I have just donated $10,000 to the Immortality Bus, which was the most rational decision of my life - Less Wrong Discussion
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A cure for aging would be almost as difficult as "cure" for entropy.
I mean, it wouldn't necessarily be physically impossible, but short of massive nanotech, I don't see how you could prevent DNA mutations and oxidative damage to extracellular proteins from accumulating over the years.
Same way you prevent cuts and bruises from accumulating over the years: Repair and replacement. Your body doesn't stay whole by preventing cuts from happening, but by effectively patching over them when they do. In principle there's no reason this couldn't be applied to DNA and oxidative damage. At least for DNA we know that mutation rates vary between organisms (as indeed do rates of aging), so it's theoretically possible to lower the mutation rate.