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NancyLebovitz comments on The horrifying importance of domain knowledge - Less Wrong Discussion
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It also seems to amount to arguing that we should take people's delusions and hallucinations at face value, as long as those are about there gender. It's also interesting that these are the only type of delusions society is, currently, expected to play along with.
If a man shows up claiming to be both Jesus and John Lennon his beliefs won't be taken seriously and he is likely to be directed towards treatment aimed at curing him of his delusion. On the other hand, if a man shows up claiming to be a woman, we are expected to take him at his word, disregard any other evidence to the contrary, and accommodate this delusion in all kinds of unreasonable ways.
On the other hand, there's a lot of hormonal and developmental variation among people, even if a large majority fall into two groups.