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adamzerner comments on Wear a Helmet While Driving a Car - Less Wrong Discussion
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The analysis uses $50k for a QALY. The analysis also assumes a normal lifespan of 80 years.
My impression is that LW readers are likely to place much higher values on their life, and to have longer expected lifespans. I could see LW readers having QALY's of 2-5 times the $50k figure. And I could see LW readers (ex. signed up for cryonics) having much longer expected lifespans.
So I could see that for many readers here, the downside should be multiplied by, perhaps an order of magnitude.