Yes, as Dagon says it is very company specific. Is there a way that you could talk to people who already work at the company who are not the people who are involved in the hiring process? If you are on Linked In, perhaps you could find out if you have some connections who would talk to you informally over the phone or in person.

Even though you would be working remotely, it may be worth it to go visit the place in person to get a feel for things and observe things that they wouldn't tell you explicitly, before making a decision of this magnitude.

Also, read the company's annual report. There are clues to its culture in there, and numbers that will help make sense of the company and the direction it is likely to take in the near future. Not enough people read the annual report when applying for a position at a company or evaluating an offer.