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RichardKennaway comments on Open thread, Aug. 10 - Aug. 16, 2015 - Less Wrong Discussion

5 Post author: MrMind 10 August 2015 07:29AM

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Comment author: RichardKennaway 14 August 2015 10:27:07PM *  2 points [-]

A few details:

In the questions about SNPs, 23andMe reports RS4570625 as G or T, not A or G, and RS4633 as C or T, not A or G.

I was surprised to see Vitamin D listed as a nootropic, and Google turns up nothing much on the subject. Fixing a deficiency of anything will likely have a positive effect on mental function, but that is drawing the boundary of "nootropic" rather wide.

Why is nicotine amplified as "gum, patch, lozenge", to the exclusion of tobacco? Cancer is a reason to not smoke tobacco, but I don't think it's a reason not to ask about it. Or are those who smoke not smart enough to be in the target population for the survey? :)

ETA: Also a typo in "SNP status of COMT RS4570625": the subtext mentions rs4680, not rs4570625. I dont know what "Val/Met" and "COMT" mean, but are those specific to RS4680 or correct for all three SNPs?

Comment author: gwern 06 September 2015 08:59:07PM 0 points [-]

In the questions about SNPs, 23andMe reports RS4570625 as G or T, not A or G, and RS4633 as C or T, not A or G.

Oops. Shouldn't've assumed they'd be the same...

but that is drawing the boundary of "nootropic" rather wide.

It is but it's still common and can be useful. The nootropics list is based on Yvain's previous nootropics survey, which I thought might be useful for comparison. (I also stole a bunch of questions from his LW survey too, figuring that they're at least battle-tested at this point.)

Why is nicotine amplified as "gum, patch, lozenge", to the exclusion of tobacco?

I have no interest in tobacco, solely nicotine. Although now that you object to that, I realize I forgot to specify vaping/e-cigs as included.

Comment author: ChristianKl 15 August 2015 04:58:14PM 0 points [-]

Val/Met

Aminoacids. Val stands for valine. Met stands for methionine.

COMT

I think COMT is Catechol-O-methyl transferase which is the protein in question.