It is? How much energy are you going to need to run detailed sims of 10^100 people?
How do you know you don't exist in the matrix? And that the true universe above ours doesn't have infinite computing power (or huge but bounded, if you don't believe in infinity.) How do you know the true laws of physics in our own universe don't allow such possibilities?
You can say these things are unlikely. That's literally specified in the problem. That doesn't resolve the paradox at all though.
Summary: the problem with Pascal's Mugging arguments is that, intuitively, some probabilities are just too small to care about. There might be a principled reason for ignoring some probabilities, namely that they violate an implicit assumption behind expected utility theory. This suggests a possible approach for formally defining a "probability small enough to ignore", though there's still a bit of arbitrariness in it.