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4hodmt comments on Is it sensible for an ambitious nonsmoker to use e-cigarettes? - Less Wrong Discussion
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If you use caffeine: No. Nicotine increases your metabolism of caffeine, meaning you need higher doses of caffeine to achieve the same effect. http://www.ncbi.nlm.nih.gov/pubmed/9022872
Personal experience suggests tolerance development is less affected than metabolism (presumably because peak caffeine levels aren't affected, although I don't have studied backing that up), which means you'll develop a tolerance to caffeine faster, as well.
That study is testing the effect of tobacco use, not pure nicotine.
EDIT -- why is this downvoted? The linked study does not test your claim. Tobacco smoking is a CYP1A2 inducer so it will increase caffeine metabolism, but I am not aware of any studies demonstrating that the nicotine is responsible for this. Tobacco smoke contains PAHs and PAHs are known CYP1A2 inducers: https://www.ncbi.nlm.nih.gov/pubmed/25911656