The mental and physical effort of many pursuits may be beyond many people...this does not change the reality of what must be done. There is nothing smug about that.

If your body has a high weight setpoint because you have a virus infection, then curing that virus infection to lower that setpoint might be a more viable strategy then trying to starve your body.

The difficulty of disciplining your diet, like anything else, decreases over time.

If that's true why do you think we see the yoyo effect?

And so again, how is this different than anything in life?

The other things you listed aren't regulated by the body around a setpoint.