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gjm comments on Open Thread, January 11-17, 2016 - Less Wrong Discussion
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Smoking cigarettes is very protecting against parkinsons. The evidence is clear, large and replicated in large samples. Hypothetically, would someone with strong genetic indications of risk for parkinsons, and genetic indications that they are protective against cardiovascular disease, lung cancer and that kind of other smoking related diseases be making a healthy choice to start smoking?.
Presumably it's the nicotine that has this effect. You can get nicotine into your system in ways less unhealthy than smoking cigarettes.