The Witness is a Myst-like puzzle/exploration game with vaguely rationalist and/or humanist overtones, by the creator of Braid. All puzzles are mazes; however, there are a wide variety of maze mechanics. I managed a somewhat minimal ending condition after ten hours or so of game time.

Not recommended for the color-blind or hearing impaired. (One subsection is devoted to mazes depending on either modality, and color discrimination is needed almost throughout, particularly in the endgame.)