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ChristianKl comments on Open Thread, Feb 8 - Feb 15, 2016 - Less Wrong Discussion
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At the end of last year there were a lot of news articles about like this about Metformin as the first anti-aging drug trial. I can't find the exact trial on clinicaltrials.gov. Can you?
Here
I found it by simply searching for "metformin aging" (which was not the first search I tried). This says that the two names are the same study.
Lemire is wrong. TAME and MILES are different. MILES is intended to just examine short-term responses (look at the registered endpoints: "Primary: Gene expression. (changes in gene expression in muscle and adipose tissue with RNA Sequencing (RNA-Seq) [ Time Frame: 12 weeks treatment ]"); TAME is intended to be a long-term 5+-year study looking for reduction in cancer and heart disease. https://clinicaltrials.gov/ct2/show/NCT02432287 is MILES, and TAME is AFAIK not yet registered on clinicaltrials.gov because they were working on approval & funding first and have not yet published a draft protocol or begun recruiting. (When I was trying to do a power analysis for TAME, I went looking, but all I found was some media mentions which suggest that a protocol has been developed as part of the application process, as one would expect, but that it's nowhere publicly available.)
Yeah, I confused the cheap talk of clinicaltrials.gov accepting targeting aging with the FDA accepting aging as a potential indication.