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johnlawrenceaspden comments on Thyroid Hormones, Chronic Fatigue and Fibromyalgia: A Hypothesis and a Proposed Experiment - Less Wrong Discussion
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Comments (36)
Absolutely agree, what I'm saying is that this test isn't very strong evidence. And that they decided to use it without considering how strong it was. They did check specificity, by measuring TSH levels in some healthy people. As far as I can tell, they didn't check sensitivity, and they never have.
I think you've just nicely summed up my argument for me. Thank you.
If you can find the bit where they checked sensitivity, and it's sound, then I'm flat wrong and I'll shut up!
They say:
(?<TSH<?) <=> (hypothyroid symptoms, gets better with T4) [in the Aristotelian sense]
I say they've shown:
(unambiguously healthy) => (0<TSH<2.5) [In the sense of plausible reasoning]
And that's all they've shown. Ever.
I am avid for evidence that they've done more than that.
My counsellor tells me that he literally cannot believe that they would have forgotten, it must be buried in the literature somewhere, and that's why we can't find it. I am perfectly happy to believe that it was a careless mistake.