Houshalter comments on What is the future of nootropic drugs? Why can't there be ones more effective than ones that have existed for 15+ years? - Less Wrong Discussion
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This isn't really an answer. There are nootropics which at least seem to make the human brain work better. The question is why new ones aren't being invented. Are the existing ones really the best possible?
And yes it's unlikely there are drugs that can magically increase IQ. But there are many other effects drugs can have other than improving IQ. Like stimulants seem to improve focus almost magically for some people.
Even the thing about evolution isn't necessarily true. Evolution is slow and random, and isn't optimizing for IQ directly, but also other things like energy usage.