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johnlawrenceaspden comments on The Thyroid Madness: Two Apparently Contradictory Studies. Proof? - Less Wrong Discussion
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I totally concur. 10mg/kg/day is a gram a day. If I took that amount of thyroid hormone, which I believe to be one of the safest drugs ever used, and of huge benefit to a large subset of the population, I would confidently expect to give myself an immediate heart attack. At the very least it would make me spectacularly ill.
So it's not buggered them up too badly.
For comparison, if you took the poor wee things' thyroids out, then you'd expect them to display horrible symptoms and die off in droves.
Oh the effect is definitely small. They do however note observable differences in the hormones down to a thousandth the dose that caused histological changes, albeit without being able to see secondary effects on quantifiable health outcomes. No idea at all if that's significant but figured I'd contribute it to the discussion of subtle thyroid dysfunction.
Well, I don't want to sound like an endocrinologist, but there aren't many chemicals which don't have some sort of effect on thyroid hormones, and if this one screwed up the system in a way measurable by hormone blood tests, it would just cause ordinary hypothyroidism, and that would get treated.
As far as I can see, the evidence for it causing any sort of subtle dysfunction is non-existent. All I've seen is the one study, but it sounds from that as though it would be safe to ingest in small doses.