John_Maxwell_IV comments on General-Purpose Questions Thread - Less Wrong Discussion
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One thing I do sometimes is search for the name of 2 different supplements on Amazon and see if I can find a commercial stack where they appear together, then check for 1 star reviews of the stack that describe a negative interaction. (This works best for stacking supplements that have similar purposes, e.g. if you're taking 2 sleep aid supplements at once, it's plausible that they both appear in a commercial stack that someone put together.)