SpaceChem eventually became too hard for me - I don't really have a methodlogical approach to the game, I'm just very good at seeing where the atoms will go. As a result, it all looks like a jumbled mess that is not reusable. The final level is too hard for the slow approach, which means that due to the difficulty spike, I've never actually finished the game.
Neither did I, and from the look of some solutions seen on Youtube, TIS-1000 seems to be even harder.
I suggest you though to look into The Sequence, it's easier but still manages to be challenging.
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