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It's really going to depend on your interests. I guess I'll just dump my favorite channels here.
I enjoy some math channels like Numberphile, computerphile, standupmaths, 3blue1brown, Vi Hart, Mathologer, singingbanana, and some of Vsauce.
For "general interesting random facts" there's Tom Scott, Wendover Productions, CGP Grey, Lindybeige, Shadiversity. and Today I Found Out.
Science/Tech/etc: engineerguy, Kurzgesagt, and C0nc0rdance.
Miscellaneous: kaptainkristian, CaptainDisillusion, and the more recent videos of suckerpinch.
Politics: I unsubscribed from most political content a long time ago. But Last Week Tonight and Vox are pretty good.
Humor: That's pretty subjective, but I think everyone should know about The Onion. Also Fitzthislewitz.