This is a linkpost for http://benjaminrosshoffman.com/against-neglectedness/
Notice that Charlie himself says:
if other charities knew he had surplus money to give away, he'd be deluged with solicitations
My impression is that charities like his are rare exceptions.
Rare in which ways? My sense is that there are a lot of things going on where someone was successful, noticed they didn't have good ways to scale up, and stopped scaling up. It's just that these things generally won't be the biggest things around, for the obvious reason.