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The great thing about Moon colony is that it ruins could survive a billion years, and will be found by the next civilization on Earth if it appears. They will found our DNA and data and return humanity to life. There are also ways to attract the attention of the next civilization to the place of our former colony.
On Mars a colony remains can't survive for so long, as Fobos will collide with Mars in 50 million years and weathering is also stronger.
The self-sustained colony on Mars probably is not possible without self-replicating robotics. If such robotics will be created it would create new space risks and new opportunities for colonization and interstellar travel. This would make Mars colony less relevant for survival.
Certainly, self replicating robots will affect our survival. I'm not sure it will go in the way we want though.