I don't think it's quite true that "fail once, fail forever", but the general point is valid that our selection process is too much about weeding-out rather than choosing the best. Also, academic doesn't seem to be very good at the negative selection that would make sense, e.g. excluding people who are likely to commit fraud or who have fundamentally anti-scientific values. (Otherwise, how can you explain how Duane Gish made it through Berkeley?)