The keyboard is irrelevant if you don't look at the keys, it's the keyboard layout that's relevant, and that's a software setting. I was very confused the first time I used a computer whose keyboard layout had been changed to Dvorak.

But there is something of a problem if you share a computer with someone who uses Qwerty, I guess. Switching back and forth might get annoying (although maybe you can set an AutoHotKey to do it?).