JonahSinick comments on Methods for treating depression - LessWrong
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This is a very good question that I don't know the answer to. Anecdotally, it seems that people try X, find that it doesn't work, then try Y, and find that it does work.
One would have to look at the details regarding what's meant by "no difference in effect." It could be that the error bars around the effect size of each are really large and overlap to such an extent that there's a ~50% chance that intervention X is better and a ~50% chance that intervention Y is better, and that this gets labelled "no difference in effect" even though it could be that there's a big difference in actual effect size.