There's this guy called William of Occam who must really be spinning in his grave right now.
I interpreted the Whitehead quote to mean that you should seek the simplest explanation that explains whatever it is you are trying to explain. This is consistent with Occam's Razor. I assumed that "distrust it" meant subject the explanation to additional tests to confirm or falsify the explanation. So, I didn't see this quote as contradicting William of Occam; instead it built on Occam's Razor to describe the essence of the scientific method.
This interpretation is supported if you look at the context of the quote:
...The aim of science is to seek
Another month, another rationality quotes thread. The rules are: