Comment author: Andy_McKenzie 15 July 2015 04:44:02PM 3 points [-]

This is fantastic and each entry is in good format to be converted to SRS (eg, Anki) cards, either backwards or forwards.

Comment author: bekkerd 13 July 2015 10:48:27AM 5 points [-]

I live in South Africa. We don't, as far as I know, have a cryonics facility comparable to, say, Alcor.

What are my options apart from "emigrate and live next to a cryonics facility"?

Also, I'm not sure if I'm misremembering, but I think it was Eliezer that said cryonics isn't really a viable option without an AI powerful enough to reverse the inevitable damage. Here's my second question, with said AI powerful enough to reverse the damage and recreate you, why would cryonics be a necessary step? Wouldn't alternative solutions also be viable? For example, brain scans while alive and then something like the Visible Human Project (body sliced into cross sections) coupled with a copy of your genome. This could perhaps also be supplemented by a daily journal. Surely a powerful enough AI would be able to recreate the human that created those writings using the information provided?

Is it a completely stupid idea?

Comment author: Andy_McKenzie 13 July 2015 06:41:21PM 1 point [-]

With regard to your first question, you could also

A) plan to move to a hospice near a facility when you are near to death

and/or

B) arrange for standby to transfer you after legal death.

Of course, there are many trade-offs involved with either. In my estimation, the most useful thing would be for you to get engaged in a local community and try to push forward on basic research and logistical issues involved, although obviously that is not an easy task.

With regard to your second question, as with everything in cryonics, this has been endlessly discussed. See a good article by Mike Dawrin on the topic here: http://chronopause.com/chronopause.com/index.php/2011/08/11/the-kurzwild-man-in-the-night/index.html

Comment author: RichardKennaway 13 July 2015 12:22:31PM 6 points [-]

For example, brain scans while alive and then something like the Visible Human Project (body sliced into cross sections) coupled with a copy of your genome. This could perhaps also be supplemented by a daily journal. Surely a powerful enough AI would be able to recreate the human that created those writings using the information provided?

Cryonics is an ambulance ride through an earthquake zone to the nearest revival facility, The distance is measured in years rather than miles, and the earthquake is the chances of history. The better the preservation, the lower the technology required to revive you, and the sooner you will reach a facility that can do it.

A "powerful enough" AI isn't magic: it cannot recover information that no longer exists. We currently don't know what must be preserved and what is redundant, beyond just "keep the brain, the rest of the body can probably be discarded, but we'll freeze it as well at extra cost if you want."

On a present-day level, the feted accomplishments of Deep Learning suggest to me that setting such algorithms to munch over a person's highly documented life might be enough to enable a more or less plausible simulation of them after death. Plausible enough at least to be offered as a comfort to the bereaved. A market opportunity! Also, fuel for a debate on whether these simulations are people.

Comment author: Andy_McKenzie 13 July 2015 06:33:08PM 2 points [-]

This is a widely discussed topic. See, eg, here: http://mindclones.blogspot.com/?m=1

In response to The Person As Input
Comment author: Andy_McKenzie 08 July 2015 03:58:05AM 5 points [-]

Great post, but IMO not that compelling of a title. Maybe add like ", or, Why God Mode is Super Lame."

Comment author: Stuart_Armstrong 30 June 2015 04:16:48PM 2 points [-]

I think differential technological development - prioritising some areas over others - is the current approach. It achirves the same result but has a higher chance of working.

Comment author: Andy_McKenzie 01 July 2015 01:39:45AM *  1 point [-]

Thanks for your response and not to be argumentative, but honest question: doesn't that mean that you want some forms of AI research to slow down, at least on a relative scale?

I personally don't see any thing wrong with this stance, but it seems to me like you're trying to suggest that this trade-off doesn't exist, and that's not at all what I took from reading Bostrom's Superintelligence.

Comment author: Andy_McKenzie 30 June 2015 01:28:04PM 4 points [-]

That we want to stop AI research. We don’t. Current AI research is very far from the risky areas and abilities. And it’s risk aware AI researchers that are most likely to figure out how to make safe AI.

Is it really the case that nobody interested in AI risk/safety wants to stop or slow down progress in AI research? It seemed to me there was perhaps at least substantial minority that wanted to do this, to buy time.

Comment author: Andy_McKenzie 26 June 2015 04:36:45AM 2 points [-]

Thanks for this post -- very interesting.

One question:

In general, medical researchers should not be doing statistics. That is a job for the tech industry.

Are you claiming that the tech industry is better at stats, or could be better at stats, if it were somehow decentralized? If the former, what's your evidence?

Comment author: V_V 24 June 2015 04:22:58PM *  9 points [-]

I've always been afraid of dying: every lurch of a plane in turbulence gets my palms sweaty; every nearly-avoided mishap I encounter while driving makes me vow to drive even less than I currently do. I won't even consider going on a cruise until I learn to swim.

Cryonics or not, if you die in a plane crash, car crash or ship sinking you will not come back.

Comment author: Andy_McKenzie 24 June 2015 10:18:41PM 5 points [-]

This is almost certainly true for most plane crashes or ship sinkings.

However, it is not necessarily true of a car crash, and this is a common misconception. In most motor vehicle accidents, individuals do not die instantaneously, and it can take many hours or even days for death to be pronounced.

This is why, for example, people are more likely to die if their car crashes in a rural area than an urban one, where they have less access to hospitals.

If you have standby services in place, and they are able to get to the hospital in a reasonable interval, then this would not affect your preservation that much, in the absence of blunt trauma to the head or cerebral hemorrhage.

As an example of this, consider one of the most famous car crashes: Princess Diana, who died three and a half hours after a particularly high-impact car crash.

So, if you accept the premise of cryonics in the average case (obviously a big if), then dying in a car crash is not necessarily going to stop the procedure from being successful.

Comment author: AndreInfante 03 June 2015 06:34:32AM 1 point [-]

What are the advantages to the hybrid approach as compared to traditional cryonics? Histological preservation? Thermal cracking? Toxicity?

Comment author: Andy_McKenzie 05 June 2015 04:26:24AM 0 points [-]

As I understand it, the major advantage is that doing the cross-linking first (e.g. w glutaraldehyde) saves you time and maintains blood vessels so that traditional cryoprotectants can diffuse more widely across brain tissue. It also may allow easier validation of the cryopreservation protocol, because you don't have as many dehydration issues.

Comment author: gwern 26 May 2015 05:05:50PM 3 points [-]

it first uses a method traditionally associated with "plastination" (glutaraldehyde perfusion), and then uses a method traditionally associated with cryonics, i.e. perfusion with a cryoprotective agent and then low temperature storage and, presumably, vitrification, which means that damage from ice crystal formation should be avoided and the brain should turn a glass state.

Is this related to the new SafeSpeed process used in http://lesswrong.com/r/discussion/lw/m8g/link_persistence_of_longterm_memory_in_vitrified/ ?

Comment author: Andy_McKenzie 26 May 2015 07:35:33PM 4 points [-]

No, I don't think so; although I don't know exactly what is in the 100 ul of "Equilibration Solution" and "Vitrification Solution", I highly doubt that they cross-link any proteins like glutaraldehyde does. Because C. elegans are so small, it is much easier for standard cryoprotectant agents to diffuse across them. So, methods to stabilize blood vessels and tissue parenchyma prior to cryoprotectant agent perfusion, which is valuable in larger animals such as pigs, are not necessary in C. elegans.

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