A sufficiently advanced simulation on any substrate would have this property - the simulated qualia would feed back on the simulated world.
Correct, but both still are just simulated. The qualia that are actually occurring are those associated with the simulator substrate, not those associated with the simulated world, and in the context of the simulated world, they would not make sense.
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Not quite reductionist enough, actually: physics is made of the relationship rules between configurations of spacetime which exist independently of any formal model of them that give us concepts like "quark" and "lepton". But digging deeper into this linguistic rathole won't clarify my point any further, so I'll drop this line of argument.
If you started perceiving two apples identically to the way you perceive two oranges, without noticing their difference in weight, smell, etc., then you or at least others around you would conclude that you were quite ill. What is your justification for believing that being unable to distinguish between things that are "computationally identical" would leave you any healthier?
If I have in front of me four apples that appear to me to be identical, but a specific two of them consistently are referred to as oranges by sources I normally trust, they are not computationally identical. If everyone perceived them as apples, I doubt I would be seen as ill.