If you think you can produce net-positive children...parents of Isaac Newton, I'm looking at you...
Considered as an altruistic endeavor, you probably do better to find existing kids with the potential to be net-positive and help them reach their potential.
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What about targeted vaccinations and other health interventions for smart kids? I don't think this is a good idea, partly because it's going to be so much less efficient than just helping everyone, but you may. Alternatively tutoring is free and with a similar level of time costs to raising your own children you could tutor a lot of others.
Not at all, that sounds great, if it were possible. Certainly generally effective health interventions sound even far more likely. But if there were a health intervention that only benefited smart kids, I would definitely consider that a net plus as to not having it exist at all.
[ETA] If it imposed some extrinsic cost on everyone else, that would be a different matter, but that's not how vaccines work, is it?