The key obstacle here is startup money. If self-replication is economically sound, then a convincing business case could be made, leading to startup funding and a trillion-dollar business.
Again, the problem is a realistic economic assessment of development cost and predicted profit. In the current funding market, there is a lot of capital chasing very few good ideas. If there is money to be made here (a big if, given low cost of manual labor) then this could be a good opportunity.
"Mining the moon" is probably too expensive to start up. Better to start with a self-replicating robot factory on Earth.
I might look at this financial analysis as a side project. Contact me if you want to get involved and have sufficient industry experience to know what you don't know.
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We may not have good measures for estimating Fb or Lb let alone Lc, but the Kepler mission gives us a pretty good estimate of Rb. You should update your estimate of the closeness of a biotic planet depending on whether your Rb prior was higher or lower than the result.
That is true. However, if "any value could be assigned to Fb", then any value can be made to come out of the Drake equation, except for an upper bound. Updating on Rb can shift around that upper bound, but it tells you nothing about the really small values that decide whether we are alone in the universe or not.