super duper nanotech

MNT isn't strictly necessary. Anabolocytes, and other speculative genetically engineered cells. They are a little more likely than Freitas' nanomedicine because, well, cells exist; which is not an argument that works for MNT.

Physical and biological aspects of renal vitrification.

Cryopreservation of organs by vitrification: perspectives and recent advances (PDF).

EDIT: I should clarify, the kidney was cooled with liquid nitrogen vapor and the lowest temperature it was exposed to was still fifty degrees above that of Liquid Nitrogen. This is important because LN2 temperature is far below the vitrification point of M22, and cooling even a little below T_g causes fracturing.

To the best of my knowledge, doctors don't experiment on patients without their consent, drill burr holes without circulation, or generally just do anything they want without fear of prosecution (Since cryonics is considered a form of interment, whether the person was completely turned into a glass sculpture or straight-frozen like so many people were does not affect the organizations). Doctors may forget rectal plugs or leave patients if funds are unavailable, though.

What do you define as 'very recently'?

Thank goodness CI and Alcor have standards.

Well, I have this theory that CI stores its neuropatients in the dewar with the dead cats in it.

Alcor: Improperly trained personnel, unkempt and ill-equipped facilities.

[...] Saul Kent invited me over to his home in Woodcrest, California to view videotapes of two Alcor cases which troubled him – but he couldn’t quite put his finger on why this was so.[...] Patients were being stabilized at a nearby hospice, transported to Alcor (~20 min away) and then CPS was discontinued, the patients were placed on the OR table and, without any ice on their heads, they were allowed to sit there at temperatures a little below normal body temperature for 1 to 1.5 hours, while burr holes were drilled, [...] smoke could be seen coming from the burr wound! Since the patient had no circulation to provide blood to carry away the enormous heat generated by the action of the burr on the bone, the temperature of the underlying bone (and brain) must have been high enough to literally cook an egg. In one case, a patient’s head was removed in the field and, because they had failed to use a rectal plug, the patient had defecated in the PIB. The result was that feces had contaminated the neck wound, and Alcor personnel were seen pouring saline over the stump of the neck whilst holding the patient’s severed head over a bucket trying to wash the fecal matter off the stump. These are just a few of the grotesque problems I observed.[...] The operating room was unkempt. The floors were scuffed, stained, dirty, and had obviously not been waxed in a long time. [...] I wouldn’t consider medical treatment in a facility with this appearance – nor for that matter would I like to dine in a restaurant with a kitchen in such a state.

Source

Cryonics Institute: Patient experimentation. No need to say anything else.

It was a snotty, and probably inappropriate remark. Basically I was commenting on the operational paradigm at CI, which is pretty much “ritual.” You sign up, you get frozen and it’s pretty much kumbaya, no matter how badly things go. And they go pretty badly. Go to: http://cryonics.org/refs.html#cases and start reading the case reports posted there. That’s pretty much my working definition of horrible. It seems apparent to me that “just getting frozen” is now all that is necessary for a ticket to tomorrow, and that anything else that is done is “just gravy,” and probably unnecessary to a happy outcome. ...Even in cases that CI perfuses, things go horribly wrong – often – and usually for to me bizarre and unfathomable (and careless) reasons. My dear friend and mentor Curtis Henderson was little more than straight frozen because CI President Ben Best had this idea that adding polyethylene glycol to the CPA solution would inhibit edema. Now the thing is, Ben had been told by his own researchers that PEG was incompatible with DMSO containing solutions, and resulted in gel formation. Nevertheless, he decided he would try this out on Curtis Henderson. He did NOT do any bench experiments, or do test mixes of solutions, let alone any animal studies to validate that this approach would in fact help reduce edema (it doesn’t). Instead, he prepared a batch of this untested mixture, and AFTER it gelled, he tried to perfuse Curtis with it. See my introduction to Thus Spake Curtis Henderson on this blog for how this affected me psychologically and emotionally. Needless to say, as soon as he tried to perfuse this goop, perfusion came to a screeching halt. They have pumped air into patient’s circulatory systems… I could go on and on, but all you need to do is really look at those patient case reports and think about everything that is going on in those cases critically.

Source

Trans Time:

The principal criticism against Trans Time was their for-profit model, in which, if funding ran out, the patients would be thawed and conventionally interred (This is what would've happened to Janice Foote and the Mills couple), unlike other organizations with a pay-once model in which the storage costs for the patients are covered for perpetuity.

I should add, Ray Mills was actually removed from suspension and placed in a chest full of dry ice.

You can also consider the now-defunct Cryonics Society of California, though I don't think any of the above organizations would go as far as talking about a non-existent facility in the present tense while the patients lay on the floor, rotting.

As soon as the first upload is successful then patient zero will realize he's got unimaginable (brain)power, will start talking in ALL CAPS, and go FOOM on the world, bad end.

Now, I have to admit I'm not too familiar with the local discourse re:uploading, but if a functional upload requires emulation down to individual ion channels (PSICS-level) and the chemical environment, I find it hard to believe we'll have the computer power to do that, a million times faster, and in a volume of space small enough that we don't have to put it under a constant waterfall of liquid Helium.

I don't expect femtotechnology or rod logic any time soon, the former may not even be possible at all and the latter is based on some dubious math from Nanosystems; so where does that leave us in terms of computing power? (Assuming, of course, that Clarke's law is a wish-fulfilling fantasy). I understand the reach of Bremermann's Limit, but it may not be possible to reach it, or there may be areas in between zero and the Limit that are unreachable for lack of a physical substrate for them.

Narrow AI and machine learning?

Eliezer's judgement was that he had to get signed up to convince people to do the same. And he didn't have much money.

What about the brain damage her tumor is causing?

Jim Glennie (A-1367) had a glioblastoma multiforme, and cryoprotective perfusion achieved the best Glycerol concentration at the time (6.02M glycerol, 1992). A-2091 (name withheld) also had a glioblastoma and reportedly "target cryoprotectant concentration was reached in the brain".

Thomas Donaldson (A-1097) had an astrocytoma (I guess Astrocytes are a kind of glial cell, but I doubt the comparison can be extended further) and his cryopreservation was very good [p.16].

I am far from an expert and simply would like to hear some authoritative commentary on this

Disclaimer: I am not medically trained.

EDIT: I'm not sure if you're referring to brain damage affecting cryoprotection or brain damage affecting her mental state and making her opt out.