If you can raise the floor for everyone, so that we're all just better, what's not to like about giving everybody that treatment?
The same that's not to like about forcing anything on someone against their will because despite their protestations you believe it's in their own best interests. You can justify an awful lot of evil with that line of argument.
Part of the problem is that reality tends not to be as simple as most thought experiments. The premise here is that you have some magic treatment that everyone can be 100% certain is safe and effective. That kind of situation does not arise in the real world. It takes a generally unjustifiable certainty in the correctness of your own beliefs to force something on someone else against their wishes because you think it is in their best interests.
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It's not a separate issue, it's the issue.
You want me to take as given the assumption that undergoing the treatment is in everyone's best interests but we're debating whether that makes it legitimate to force the treatment on people who are refusing it. Most of them are presumably refusing the treatment because they don't believe it is in their best interests. That fact should make you question your original assumption that the treatment is in everyone's best interests, or you have to bite the bullet and say that you are right, they are wrong and as a result their opinions on the matter can just be ignored.
Just out of curiosity, are you for or against the Friendly AI project? I tend to think that it might go against the expressed beforehand will of a lot of people, who would rather watch Simpsons and have sex than have their lives radically transformed by some oversized toaster.