"And both spatial infinity and inflation are standard in the current model of physics."
As mentioned by a commenter above, spatial infinity is by no means required or implied by physical observation. Non-compact space-times are allowed by general relativity, but so are compact tori (which is a very real possibility) or a plethora of bizarre geometries which have been ruled out by experimental evidence.
Inflation is an interesting theory which agrees well with the small (relative to other areas of physics) amount of cosmological data which has been collected. However, the data by no means implies inflation. In fact, the term "inflation" refers to a huge zoo of models which have many unexplained parameters which can be tuned to fit the date. Physicists are far from absolutely confident in the inflationary picture.
Furthermore, there are serious, serious problems with Many Worlds Interpretation (and likewise for Mangled Worlds), which you neglect to mention here.
I enjoy your take on Quantum Mechanics, Eliezer, and I recommend this blog to everyone I know. I agree with you that Copenhagen untenable and the MWI is the current best idea. But you talk about some of your ideas like it's obvious and accepted by anyone who isn't an idiot. This does your readers a disservice.
I realize that this is a blog and not a refereed journal, so I can't expect you to follow all the rules. But I can appeal to your commitment to honesty in asking you to express the uncertainty of your ideas and to defer when necessary to the academic establishment.
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Excellent post Eliezer. I have just a small quibble: it should be made clear that decoherance and the many worlds interpretations are logically distinct. Many physicists, especially condensed matter physicist working on quantum computation/information, use models of microscopic decoherance on a daily basis while remaining agnostic about collapse. These models of decoherance (used for so-called "partial measurement") are directly experimentally testable.
Maybe a better term for what you are talking about is macroscopic decoherance. As of right now, no one has ever created serious macroscopic superpositions. Macroscopic decoherance, and hence the many worlds interpretation, rely on extrapolating microscopic observed phenomena.
If there's one lesson we can take from the history of physics, it's that everytime new experimental "regimes" are probed (e.g. large velocities, small sizes, large mass densities, large energies), phenomena are observed which lead to new theories (special relativity, quantum mechanics, general relativity, and the standard model, respectively). This is part of the reason I find it likely that the peculiar implications of uncollapsed hermitian evolution are simply the artifacts of using quantum mechanics outside its regime of applicability.
Here at UC Santa Barbara, Dirk Bouwmeester is trying to probe this macroscopic regime by superposing a cantilever that is ~50 microns across--big enough to see with an optical microscope!