You could argue that mere destruction would be easier than converting everything to orgasmium, but both seem hard enough to basically require a superintelligence.
We can kill everyone today or in the near future by diverting a large asteroid to crash into Earth, or by engineering a super-plague. Doing either would take significant resources but isn't anywhere near requiring a superintelligence. In comparison, converting everything to orgasmium seems much harder and is far beyond our current technological capabilities.
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I'm not an expert on bioweapons, but I note that the paper you cite is dated 2005, before the advent of synthetic biology. The recent report from FHI seems to consider bioweapons to be a realistic existential risk.
Thanks, I hadn't seen that. Interesting (and scary).