There is no 'open question' issue here - "mistake", like "exothermic", does not have any prior metaphysical meaning. We are free to define it as we wish, naturalistically.
I'm having trouble with the word "metaphysical". In order for me to make sense of the claim that "mistake" and "exothermic" do not have prior metaphysical meanings, I would like to see some examples of words that do have prior metaphysical meanings, so that I can try to figure out from contrasting examples of having and not having prior metaphysical meanings what it means to have a prior metaphysical meaning. Because at the moment I don't know what you're talking about.
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What does "subverted" mean in this context? For example I devote a lot of resources into thinking about philosophical problems which does not seem to contribute to my genetic fitness. Have I been "subverted" by a selfish meme (i.e., the one that says "the unexamined life is not worth living")? If so, I don't feel any urge to try to self-modify away from this. Couldn't a utilitarian feel the same?
A utilitarian might well be indifferent to the self-serving nature of the the meme. But, as I recall, you brought up the question in response to my suggestion that my own (genetic) instincts derive a kind of nobility from their origin in the biological process of natural selection for organism fitness. Would our hypothetical utilitarian be proud of the origin of his meme in the cultural process of selection for meme self-promotion?