Apparently, most of what one sees on Lie To Me is spurious. At any rate, viewing the show causes people to make more false positive identifications of deception relative to a control group, without being any more accurate at catching real deception:
The Impact of Lie To Me on Viewers' Actual Ability to Detect Deception
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If anyone can bear more of this, Poppers argument against induction using Bayes is being discussed here