I think this is usually defined as being in a state where what you observe is liable to create negative emotions in you (or in some definitions, a variety of emotions).
I think that the variety of emotions definition makes more sense. It's about being open to possibilities, even if some of those possibilities are heartbreaking.
In other words, it is about taking emotional risks. I suppose it would be possible to go through life taking as few risks as possible....but such a life would be stunted in some ways. Risk-taking is not always valuable, but it is sometimes valuable.
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I know that negative prescription drug interactions are a big deal. Should I be worried about negative interactions among legal supplements I take like Coq10, Vit D, glucosamine, curcumin, desiccated liver, Bacopa Monnieri, or NAC?
There are software programs that have databases of drug and supplement interactions. Also, pharmacists tend to know more about these things than doctors. So, you could find a database and search it, and/or ask a pharmacist. There isn't as much information available on supplements as there is about drugs, so it's hard to answer the question with a lot of certainty.