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Comment author: gwern 14 May 2015 09:35:45PM *  0 points [-]

My currently unfilled requests on /r/scholar:

https://www.reddit.com/r/Scholar/comments/29hi38/request_2_dissertations_on_online_learning/ :

  1. Santo, S.A.: "Virtual learning, personality, and learning styles". Dissertation Abstracts International Section A, Humanities & Social Sciences, 62, pp. 137 (2001) (slides: http://sloanconsortium.org/conference/proceedings/1999/pdf/99_santo.pdf )
  2. Zobdeh-Asadi, S.: "Differences in personality factors and learners' preference for traditional versus online education". Dissertation Abstract International Section A: Humanities & Social Sciences, 65(2-A), pp. 436 (2004)

https://www.reddit.com/r/Scholar/comments/2xlrv5/article_modafinil_the_unique_properties_of_a_new/ :

https://www.reddit.com/r/Scholar/comments/2xpgig/article_is_lithium_a_neuroprotective_agent/ :

https://www.reddit.com/r/Scholar/comments/32z239/can_transcranial_direct_current_stimulation/ :

https://www.reddit.com/r/Scholar/comments/34nlq5/studying_with_music_is_the_irrelevant_speech/

  • Book chapter: Kantner, J. (2009). "Studying with music: Is the irrelevant speech effect relevant?". In M. R. Kelley (Ed.), Applied memory (pp. 19-40). Hauppauge, NY US: Nova Science Publishers.

https://www.reddit.com/r/Scholar/comments/34nsug/article_the_effect_of_music_as_a_distraction_on/ :

https://www.reddit.com/r/Scholar/comments/352qyo/article_gwas_and_metaanalysis_in_aginglongevity/ :

Comment author: VincentYu 23 May 2015 01:54:44AM 2 points [-]

I'm still waiting for Schretlen et al.

Comment author: VincentYu 21 May 2015 07:18:56AM 0 points [-]

Dale and Krueger's paper was revised and published in the Journal of Human Resources under the new title "Estimating the effects of college characteristics over the career using administrative earnings data".

Comment author: torekp 17 May 2015 12:34:56AM 1 point [-]

Good question, thanks. Yes, I do think that "mind uploading", suitably loosely defined, will be available first on a non-WBE platform. I'm assuming that human-level AGI relatively quickly becomes superhuman-level, to the point where imitating the behavior of a specific individual becomes a possibility.

Comment author: VincentYu 17 May 2015 04:15:28AM 0 points [-]

I see. In GAZP vs. GLUT, Eliezer argues that the only way to feasibly create a perfect imitation of a specific human brain is to do computations that correspond in some way to the functional roles behind mental states, which will produce identical conscious experiences according to functionalism.

Comment author: torekp 15 May 2015 12:51:45PM *  1 point [-]

Hold the holy water, and please stop attributing views to me I don't hold and didn't imply. There's no dichotomy. "Subjective" can just mean "in your head"; that's consistent with there being objective facts about it.

Referring to the analogy, Gasoline Gal at least doesn't care what kind of metal the engine is made from, so if we can at least agree that computations and information processes are the important thing, then it's just a question of figuring out which ones are important / simulating them as closely as possible just to be sure.

I lean heavily toward the view that information processes are the important thing. That's why I made Gasoline Gal not care about the metals. Note, information processes are algorithms, not just functions. For uploading, that means whole brain emulation. In my underinformed opinion, whole brain emulation is not the Way to AGI if you just want AGI. At some point, then, AGI will be available while WBE systems will be way behind; and so, uploaders will at least temporarily face a deeply serious choice on this issue.

Comment author: VincentYu 16 May 2015 09:07:41AM *  1 point [-]

For uploading, that means whole brain emulation. In my underinformed opinion, whole brain emulation is not the Way to AGI if you just want AGI. At some point, then, AGI will be available while WBE systems will be way behind; and so, uploaders will at least temporarily face a deeply serious choice on this issue.

Are you suggesting that mind uploading to a non-WBE platform will be available before WBE? I don't think this is a common belief; uploading almost exclusively refers to WBE. See, for instance, Sandberg and Bostrom (2008), who don't distinguish between WBE and uploading:

Whole brain emulation, often informally called “uploading” or “downloading”, has been the subject of much science fiction and also some preliminary studies.

I think it is indeed a common belief that AGI may come before WBE, but as far as I know, it is not commonly believed that AGI will provide an alternative route to WBE, because human minds will likely not be feasibly translatable to the AGI architectures that we come up with.

Comment author: Clarity 15 May 2015 07:43:00AM 1 point [-]

I'm interested in reviewing the data on disabling diseases by loss of income and quality of life after reading the following:

'Obsessive-compulsive disorder (OCD) has been classified by the World Health Organization as one of the top 10 most disabling diseases with respect to loss of income and quality of life [4]. ... [4] National Collaborating Centre for Mental Health. Common mental health disorders, identification and pathways to care. London: National Institute for Health and Clinical Excellence; 2011.'

-http://www.racgp.org.au/afp/2013/september/ocd/#4

The outline for the 2011 reference is available here: http://www.ncbi.nlm.nih.gov/books/NBK92266/

I've tried combining the phrases of interest like quality of life and disability with the title of the 2011 work and saw no relevant results.

Any advice on how to proceed, alternative strategies or directions to other sources and/or data?

Comment author: VincentYu 16 May 2015 08:46:01AM *  1 point [-]

The relevant paragraph is in Section 2.2.5:

OCD is ranked by the WHO in the top ten of the most disabling illnesses by lost income and decreased quality of life (Bobes et al., 2001). The severity of OCD differs markedly from one person to another. While some people may be able to hide their OCD from their own family, the disorder may have a major negative impact on social relationships leading to frequent family and marital discord or dissatisfaction, separation or divorce (Koran, 2000). It also interferes with leisure activities (Antony et al., 1998) and with a person’s ability to study or work, leading to diminished educational and/or occupational attainment and unemployment (Koran, 2000; Leon et al., 1995). The social cost (that is the person’s inability to fully function in society) has been estimated as US$5.9 billion in 1990, or 70.4% of the total economic cost of OCD (DuPont et al., 1995).

Following the Bobes et al. citation yields:

Obsessive-compulsive disorder is the fourth most common psychiatric disorder, occurring in 2–3% of the U.S. population [14]. Furthermore, OCD is a chronic and disabling illness that impacts negatively on the academic, occupational, social, and family function of patients [11, 12, 17]. This impact carries over onto their families, friends, and society [12]. Indeed, OCD ranks tenth in the World Bank’s and WHO’s ten leading causes of disability and, in the case of women aged 15–44 years, OCD occupies the fifth position [22]. In spite of this situation, to our knowledge data on quality of life and disability has scarcely been reported in OCD patients.

Reference 22 is to "WHO Fact Sheet no. 217", which no longer exists. Luckily, the Wayback Machine has a copy. The relevant point:

It is also of great significance that 5 of the 10 leading causes of disability worldwide (major depression, schizophrenia, bipolar disorders, alcohol use, obsessive compulsive disorders) are mental problems. They are as relevant in developing countries as they are in industrialised societies

Unfortunately, there is no citation and it does not precisely match Bobes et al's claims. Neither Bobes et al. nor the WHO fact sheet refers to lost income, so the reference to that in the original claim is wholly unsubstantiated by these citations.

Comment author: gwern 14 May 2015 09:35:45PM *  0 points [-]

My currently unfilled requests on /r/scholar:

https://www.reddit.com/r/Scholar/comments/29hi38/request_2_dissertations_on_online_learning/ :

  1. Santo, S.A.: "Virtual learning, personality, and learning styles". Dissertation Abstracts International Section A, Humanities & Social Sciences, 62, pp. 137 (2001) (slides: http://sloanconsortium.org/conference/proceedings/1999/pdf/99_santo.pdf )
  2. Zobdeh-Asadi, S.: "Differences in personality factors and learners' preference for traditional versus online education". Dissertation Abstract International Section A: Humanities & Social Sciences, 65(2-A), pp. 436 (2004)

https://www.reddit.com/r/Scholar/comments/2xlrv5/article_modafinil_the_unique_properties_of_a_new/ :

https://www.reddit.com/r/Scholar/comments/2xpgig/article_is_lithium_a_neuroprotective_agent/ :

https://www.reddit.com/r/Scholar/comments/32z239/can_transcranial_direct_current_stimulation/ :

https://www.reddit.com/r/Scholar/comments/34nlq5/studying_with_music_is_the_irrelevant_speech/

  • Book chapter: Kantner, J. (2009). "Studying with music: Is the irrelevant speech effect relevant?". In M. R. Kelley (Ed.), Applied memory (pp. 19-40). Hauppauge, NY US: Nova Science Publishers.

https://www.reddit.com/r/Scholar/comments/34nsug/article_the_effect_of_music_as_a_distraction_on/ :

https://www.reddit.com/r/Scholar/comments/352qyo/article_gwas_and_metaanalysis_in_aginglongevity/ :

Comment author: VincentYu 16 May 2015 07:45:10AM 0 points [-]

The last one.

I don't think I can get the two dissertations. I'll put in ILL requests for the other papers over the next week.

Comment author: Clarity 14 May 2015 02:21:46AM 0 points [-]

Requesting sections 3.2-3.6 of Rational Choice in an Uncertain World or other substantiating research

"...'experts are good at discovering the key variables in their prediction. They are just bad at combining multiple sources of information, ignoring irrelevant factors and coming to an overall judgment in (sections 3.2-3.6 of Rational Choice in an Uncertain World)..."

-http://www.eaventures.org/our-method/

Comment author: VincentYu 14 May 2015 06:56:39AM 0 points [-]

Chapter 3 is available from the publisher as a sample.

(BTW, this is an old help desk thread; the newest one is here.)

Comment author: rseiter 05 April 2015 04:42:35PM 2 points [-]

Thanks for the explanation and tips! I used your procedure and ended up with the same 131MB file. Interestingly I did not need to remove the "--" entries. I have been exchanging email with BGI and they indicated files could have significantly different number of entries (but I am surprised at >3x!). Is there any chance your sequencing had greater than 4x coverage? My VCF file is queued up and should be available in a few months which should help clarify what I am seeing.

Comment author: VincentYu 07 April 2015 09:50:41AM 0 points [-]

Is there any chance your sequencing had greater than 4x coverage?

I don't know. How do I find out?

Comment author: VincentYu 07 April 2015 09:41:48AM 0 points [-]

There is the References & Resources for LessWrong (last updated in 2011), which has a good selection of older posts and other resources by subject.

Comment author: rseiter 30 March 2015 06:12:24PM 2 points [-]

I received a similar email and was able to download my genome file a few days ago. The file is 23andMe format output by Plink. It was text even though it had a .gz suffix. I had trouble uploading the file to Promethease, but was able to get it working by changing the header to one copied from an actual 23andMe file and removing the missing (--) SNPs. Unfortunately, despite being ~125MB (~5x the size of an example 23andMe file I have) my file is missing many of the 23andMe SNPs (7948 genotypes annotated in Promethease vs. 20k+ for the 23andMe example). I have an email in to BGI requesting additional information. For example, Promethease directly supports the dbSNPAnnotated.bz2 Complete Genomics file and I was hoping to get a copy of that file for my data.

Have you had any success analyzing your results? Would anyone be interested in starting a discussion group for analyzing our BGI results?

Comment author: VincentYu 04 April 2015 05:58:16AM *  2 points [-]

Are you sure you've downloaded your entire genome file? My uncompressed file is about 500 MB, and I got about 26000 annotations on Promethease. It seems like your file might have gotten truncated during the download.

Short step-by-step guide for those who want to get their genome annotated by Promethease:

  1. Use the 'Download All Files' link on the SpiderOak page to download your genome file.*
  2. Unzip then gunzip to get the raw text file genome.txt.
  3. Open the file in a text editor. Remove all the commented lines at beginning of the file except the last one (i.e., keep the line starting with # rsid; Promethease chokes if you don't) and save. This is required to get Promethease to recognize the file.
  4. (optional) Compress the edited file with zip, gzip, or bzip2 to save upload time and bandwidth.
  5. Upload to Promethease and follow the directions there.

* I advise against downloading the genome.txt.gz file directly because for some reason SpiderOak has Content-encoding: gzip in their HTTP response header, which means that browsers will transparently uncompress that file. This makes me uneasy because there is no checksum provided for the (somewhat large) plain text file, so we have little protection against corruption and truncation. In contrast, by using 'Download All Files' to download everything in a zip, the data's integrity will be automatically verified against CRC-32 checksums when we unzip and gunzip locally.

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