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Apparently a hedge fundie made 4 billion and is giving most of it away to what the WSJ describes as a "moneyball" approach to giving.
Some background: medicinal chemists are responsible for identifying drug candidates, usually by screening large (10^6) libraries of combinatorially generated molecules. Some of these hits turn out to be biologically active, and then it's up to the medicinal chemists to decide whether these hits are false positives or not, and further, to synthesize analogous compounds to see if they can tweak the biological activity of each compound.
It's in this 'synthesizing analogous compounds' step that subjective judgment comes in, with Lipinski's rule of five being the most 'basic' of the heuristics, and with most medicinal chemists adopting more and more complex heuristics. Or, as this paper shows, perhaps they're just deluding themselves and their true metric is something very simple, and after making their decision, they dress it up with fancy post-hoc rationalizations.
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