Any present version of a protein that evolved >1,000,000,000 years ago is only homologous and not identical to it's predecessor.
just would take too long
A billion years does happen to be really long, especially if you have very many tiny spots of life all around the planets that evolve on their own.
What works in a lab in a few years is radically different than what works in billions of billions of parallel experiments done for billions of years.
Pointing out homologs still leaves the problem of tranversing a highly spiked fitness landscape, but if this is ever demonstrated on say, a new protein complex in E. coli, I'd say, you win
How do you judge something to be a new protein complex? Bacteria's pass their plasmides around.
E.coli likely hasn't good radically new protein complexes in the last millions of years so anything it does presently is highly optimized and proteins are only homologous to their original functions.
I think you are more likely to find new things in bacteria's that actually adept to radically new enviroments.
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The 10,000 Year Explosion disagrees; to quote my own earlier summary of it:
Allele variation that generates different heights or melanin within various races, point mutations like sickle cell, the mutations that generate lactose tolerance in adults, or that affect our ability to process alcohol, are micro-evolution. They do not extrapolate to new tissues and proteins that define different species. I accept that polar bears descended from a brown bear, that the short-limb, heat-conserving body of an Eskimo was the result of the standard evolutionary scenario. I have no reason to doubt the Earth existed for billions of years.
Humans have hundreds of orphan genes unique among mammals. To say this is just an extension of micro-evolution relies on the possibility it could happen, but you need 50MM new nucleotides that work to arise within 500k generations. Genetic drift could generate that many mutations, but the chance these would be functional assumes proteins are extremely promiscuous. When you look at what it takes to make a functioning protein within the state-space of all amino acid sequences, and how proteins work in concert with promoter genes, RNA editing, and connecting to other proteins, the probability this happened via mutation and selection is like a monkey typing a couple pages of Shakespeare: possible, but not probable.
This all argues for a Creator, who could be an alien, or an adolescent Sim City programmer in a different dimension, or a really smart and powerful guy that looks like Charlton Heston. The argument for a Christian God relies on issues outside of argument by design