We don't want to be confused with the uncritically thinking masses - the apologists of homoeopathy or astrology justifying their views by "yeah, I don't know how it works either, but it's useful!";
I think this statement underscores the problem with rejecting the correspondence theory of truth. Yes, one can say "homeopathy works", but what does that mean ? How do you evaluate whether any given model is useful of not ? If you reject the notion of an external reality that is accessible to us in at least some way, then you cannot really measure the performance of your models against any kind of a common standard. All you've got left are your internal thoughts and feelings, and, as it turns out, certain goals (such as "eradicate polio" or "talk to people very far away") cannot be achieved based on your feelings alone.
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Right, but I meant, in practice.
Observations of what ? Since you do not have access to infinite computation or perfect observations in practice, you end up observing the outputs of models, as suggested in the original post.
What is it that makes their accumulated knowledge worthy of being relied upon ?
I agree with pragmatist (the OP) that this is a problem for the correspondence theory of truth.
Usefulness? Just don't say "experimental evidence". Don't oversimplify epistemic justification. There are many aspects - how well knowledge fits with existing models, with observations, what is it's predictive power, what is it's instrumental value (does it help to achieve one's goals) etc. For example, we don't have any experimental evidence that smoking causes cancer in humans, but we nevertheless believe that is does. The power of Bayesian approach is in the mechanism to fuse together all these different forms of evidence and to arrive at a single posterior probability.